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pentobarbital will decrease the level or effect of lopinavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.pentobarbital will lessen the level or influence of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Lack of, or reduced reaction to tofacitinib may arise when c